Publications by authors named "J Feugeas"
Article Synopsis
- Colorectal cancer is a major health concern, ranking as the third leading cause of cancer deaths globally in 2022, and early detection through screening is crucial for improving outcomes.
- Using bioinformatics, researchers identified new DNA methylation biomarkers (COL25A1 and METAP1D) for colorectal cancer by analyzing extensive genetic data, which was then validated through specific testing on samples from patients and healthy individuals.
- The biomarkers showed high specificity (100%) and moderate sensitivity (49%) for detecting colorectal cancer in blood samples, suggesting their potential for noninvasive screening, though further studies are needed to confirm their practical use in clinical settings.
Background: Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments occurs almost constantly. Compared to primary tumors, there are still limited genomic data that has been obtained from metastatic samples.
Methods: We aimed to characterize metastatic ccRCC by way of whole-genome analyses of metastatic formalin-fixed samples, using OncoScan technology.
Breast cancer brain metastases are a challenging daily practice, and the biological link between gene mutations and metastatic spread to the brain remains to be determined. Here, we performed a meta-analysis on genomic data obtained from primary tumors, extracerebral metastases and brain metastases, to identify gene alterations associated with metastatic processes in the brain. Articles with relevant findings were selected using Medline via PubMed, from January 1999 up to February 2022.
View Article and Find Full Text PDFRNA polymerase (Pol) III transcribes short untranslated RNAs that contribute to the regulation of gene expression. Two isoforms of human Pol III have been described that differ by the presence of the POLR3G/RPC32α or POLR3GL/RPC32β subunits. POLR3G was found to be expressed in embryonic stem cells and at least a subset of transformed cells, whereas POLR3GL shows a ubiquitous expression pattern.
View Article and Find Full Text PDFIron deficiency is a significant comorbidity of heart failure (HF), defined as the inability of the myocardium to provide sufficient blood flow. However, iron deficiency remains insufficiently detected. Iron-deficiency anemia, defined as a decrease in hemoglobin caused by iron deficiency, is a late consequence of iron deficiency, and the symptoms of iron deficiency, which are not specific, are often confused with those of HF or comorbidities.
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