Publications by authors named "J Fertmann"
Background: Lung transplantation (LuTX) can be the last resort for patients with end-stage lung diseases. In the last decades, improvements were implemented in transplant medicine, from immunosuppression throughout preservation of the donor organ to enhance lung allograft survival. This retrospective study aims to illustrate the development of the LuTX-program at the University Hospital of Munich, LMU, Munich, Germany, since its launch in 1990 by depicting and comparing postoperative outcome.
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- HLA mismatches between lung transplant donors and recipients can lead to the formation of donor-specific antibodies, particularly HLA-DQ-dnDSA, which can negatively affect transplant outcomes.
- The study analyzed data from 183 lung transplant patients from 2012 to 2020, finding that 22.9% developed HLA-DQ-dnDSA, with homozygous HLA-DQ patients at a higher risk compared to heterozygous patients.
- The research identified specific HLA-DQ combinations and eplets that increase the risk for dnDSA development, suggesting that improving immunological compatibility could enhance graft outcomes.
Background: There are various reconstructive methods after total sternectomy. Reproducibility is scarce due to overall small patient numbers. Therefore we present a standardized, interdisciplinary approach for thoracic and plastic surgery.
View Article and Find Full Text PDFIntroduction: Environmental pollutants injure the mucociliary elevator, thereby provoking disease progression in chronic obstructive pulmonary disease (COPD). Epithelial resilience mechanisms to environmental nanoparticles in health and disease are poorly characterised.
Methods: We delineated the impact of prevalent pollutants such as carbon and zinc oxide nanoparticles, on cellular function and progeny in primary human bronchial epithelial cells (pHBECs) from end-stage COPD (COPD-IV, n=4), early disease (COPD-II, n=3) and pulmonary healthy individuals (n=4).