Publications by authors named "J Ferruzzi"
Article Synopsis
- ECM stiffness affects progenitor cell differentiation, but it's hard to study its effects in developing organs due to limited tools.
- Researchers applied photocrosslinking using Rose Bengal to stiffen the pulmonary mesenchyme in embryonic lungs, impacting morphogenesis without harming cell growth.
- Their findings reveal that increased stiffness can inhibit airway branching and suggest that photocrosslinking could be used in other developing tissues to explore mechanical property changes.
Article Synopsis
- Cetuximab (Cet)-IRDye800CW is an antibody-IRDye800CW conjugate that shows promise for identifying tumor margins during fluorescence-guided surgery and is being explored for post-surgery treatment of residual cancer cells using photodynamic therapy (PDT).
- The study highlights that increasing the number of dye molecules attached to the antibody from 2 to 11 enhances the effectiveness of Cet-IRDye800CW, enabling it to produce reactive species that can harm cancer cells, inducing approximately 90% phototoxicity in FaDu head and neck cancer cells.
- Antibody-targeted PDT with the higher dye payload offers improved cancer cell specificity and reduced toxicity in non-cancerous
Desmoplasia in pancreatic ductal adenocarcinoma (PDAC) limits the penetration and efficacy of therapies. It has been previously shown that photodynamic priming (PDP) using EGFR targeted photoactivable multi-inhibitor liposomes remediates desmoplasia in PDAC and doubles overall survival. Here, bifunctional PD-L1 immune checkpoint targeted photoactivable liposomes (iTPALs) that mediate both PDP and PD-L1 blockade are presented.
View Article and Find Full Text PDFThe arterial stiffening is a strong independent predictor of cardiovascular risk and has been used to characterize the biological age of arteries ('arterial age'). Here we revealed that the Fbln5 gene knockout (Fbln5 ) significantly increases the arterial stiffening for both male and female mice. We also showed that the arterial stiffening increases with natural aging, but the stiffening effect of Fbln5 is much more severe than aging.
View Article and Find Full Text PDFProgress continues in the field of cancer biology, yet much remains to be unveiled regarding the mechanisms of cancer invasion. In particular, complex biophysical mechanisms enable a tumor to remodel the surrounding extracellular matrix (ECM), allowing cells to invade alone or collectively. Tumor spheroids cultured in collagen represent a simplified, reproducible 3D model system, which is sufficiently complex to recapitulate the evolving organization of cells and interaction with the ECM that occur during invasion.
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