Publications by authors named "J Ferrieres"
Cerebrotendinous xanthomatosis: a literature review and case study.
Front Cardiovasc Med
December 2024
Cerebrotendinous xanthomatosis (CTX) is a rare but treatable inherited neurometabolic disorder that can lead to severe sequelae if left untreated. Chenodeoxycholic acid is a safe and effective treatment for CTX. Early diagnosis is essential to improve patient outcomes.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between metabolic drugs (like those for diabetes and cholesterol) and cardiovascular diseases (CVD) in the Lebanese population, utilizing data from a nationwide survey of 2048 participants.
- Key findings indicate that factors such as higher adherence to the Lebanese Mediterranean Diet, hypertension, diabetes, dyslipidemia, family history of CVD, and smoking habits are associated with an increased risk of CVD, while higher income levels appear to lower this risk.
- Interestingly, the study found that neither hypoglycemic nor lipid-lowering medications had a significant impact on CVD risk, though lifestyle and socio-economic status played notable roles in different patient subgroups.
Epidemiology of cardiovascular risk factors: Non-behavioural risk factors.
Arch Cardiovasc Dis
December 2024
Article Synopsis
- Cardiovascular disease is the leading cause of death globally and a major concern in France, heavily influenced by modifiable risk factors like obesity, diabetes, hypertension, and high cholesterol levels.
- In 2015, significant prevalence rates for these conditions were reported among adults aged 18-74, with obesity at 17.2% and diabetes at 7.4%, yet awareness of these conditions was low among those affected.
- A push for better prevention methods, especially through nutrition and education, is essential to tackle these cardiovascular risk factors, with a noted importance on also addressing women's specific health issues that impact cardiovascular risk.
Article Synopsis
- PCSK9 is crucial for regulating LDL-cholesterol and certain variants, like p.Ser127Arg, lead to higher cholesterol levels and are mainly found in France, with few in South Africa and Norway due to a common ancestor effect.
- The study analyzed 14 p.Ser127Arg carriers from eight families and compared them with other variants to understand their genetic background and health impact.
- Results indicated that the common ancestor lived about 775 years ago, and carriers of p.Ser127Arg had significantly higher LDL-C levels, suggesting it may have a stronger effect on cholesterol levels compared to other mutations.
Aims: Women are less likely to receive lipid-lowering therapy (LLT) after acute myocardial infarction (AMI). We analysed whether this under-prescription currently persists and has an impact on long-term outcomes.
Methods And Results: The FAST-MI programme consists of nationwide registries including all patients admitted for AMI ≤ 48 h from onset over a 1 month period in 2005, 2010, and 2015, with long-term follow-up.