Publications by authors named "J Ferreri"
Article Synopsis
- Clostridial gas gangrene (CGG) is a severe, fast-spreading infection with near-100% mortality if untreated, often linked to trauma but can arise spontaneously in immunocompromised individuals.
- Quick recognition and treatment are crucial, as CGG symptoms develop rapidly and require urgent surgical and antimicrobial care.
- A case study of a 73-year-old woman with spontaneous CGG illustrates the disease's severity; despite intensive treatment, she died from metastatic infection within 48 hours.
Purpose: There is increasing evidence that the ovarian extracellular matrix (ECM) plays a critical role in follicle development. The rigidity of the cortical ECM limits expansion of the follicle and consequently oocyte maturation, maintaining the follicle in its quiescent state. Quiescent primordial, primary, and secondary follicles still exist in primary ovarian insufficiency (POI) patients, and techniques as in vitro activation (IVA) and drug-free IVA have recently been developed aiming to activate these follicles based on the Hippo signaling disruption that is essential in mechanotransduction.
View Article and Find Full Text PDFUsually poor ovarian response (POR) to gonadotropins reflects a diminished ovarian reserve (DOR) that gives place to few recruitable follicles despite aggressive stimulation. The reduction in the quantity and quality of the oocytes with advanced age is physiological. However, some women experience DOR much earlier and become prematurely infertile, producing an accelerated follicular depletion towards primary ovarian insufficiency (POI).
View Article and Find Full Text PDFDrug-Free IVA has been recently introduced as a therapeutic option for patients with Primary Ovarian Insufficiency (POI). Despite the existing limited results, it can be considered as a promising option for these patients to achieve their own offspring. Here we report the case of a 35-year-old woman diagnosed with POI at 30 years of age.
View Article and Find Full Text PDFBackground: Tropical cyclone epidemiology can be advanced through exposure assessment methods that are comprehensive and consistent across space and time, as these facilitate multiyear, multistorm studies. Further, an understanding of patterns in and between exposure metrics that are based on specific hazards of the storm can help in designing tropical cyclone epidemiological research.
Objectives: ) Provide an open-source data set for tropical cyclone exposure assessment for epidemiological research; and ) investigate patterns and agreement between county-level assessments of tropical cyclone exposure based on different storm hazards.