Publications by authors named "J Ferre"
Article Synopsis
- The study investigates the effectiveness of amide proton transfer-weighted imaging (APTwi) for differentiating between brain tumors and tumor mimics in a clinical setting, analyzing data from 156 patients.
- Results revealed that the APT signal intensity (APT-SI) is significantly higher in tumors compared to tumor mimics, particularly in high-grade gliomas and specific tumor subtypes like mesenchymal tumors.
- The findings suggest that while high APT-SI is more common in aggressive tumors, it can also appear in certain low-grade tumors and tumor mimics, indicating a potential limitation in using APTwi as a definitive diagnostic tool.
Background And Objectives: The dynamics of microstructural spinal cord (SC) damage and repair in people with multiple sclerosis (pwMS) and their clinical relevance have yet to be explored. We set out to describe patient-specific profiles of microstructural SC damage and change during the first year after MS diagnosis and to investigate their associations with disability and SC atrophy at 5 years.
Methods: We performed a longitudinal monocentric cohort study among patients with relapsing-remitting MS: first relapse <1 year, no relapse <1 month, and high initial severity on MRI (>9 T2 lesions on brain MRI and/or initial myelitis).
Background: Mechanical thrombectomy (MT) is an effective treatment for acute ischemic stroke from large vessel occlusion (LVO). While embolization to a new territory (ENT) after MT is well-documented, data on embolization in the same distal territory (EDT) are limited. Achieving modified Treatment In Cerebral Infarction (mTICI) 3 reperfusion presents significant clinical benefits over mTICI 2b/2c, necessitating strategies to reduce both ENT and EDT.
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- The study aimed to track the outcomes of patients with brain arteriovenous malformations (AVMs) who were managed conservatively, revealing key statistics on related morbidity and mortality over a 10-year period.
- Out of 1010 patients initially recruited, 434 were analyzed, with a majority having unruptured low-grade AVMs, demonstrating a 5% occurrence of serious outcomes and a higher risk in those with a history of rupture or older age.
- During the follow-up of approximately 3.2 years, 8% of patients experienced major intracranial hemorrhages, highlighting the ongoing risks associated with conservative management of AVMs.
The resistance to the insecticidal protein Cry1Ac from the bacterium (Bt) in the cabbage looper, , has previously been identified to be associated with a frameshift mutation in the ABC transporter ABCC2 gene and with altered expression of the aminopeptidase N (APN) genes and , shown as missing of the 110-kDa APN1 (phenotype APN1¯) in larval midgut brush border membrane vesicles (BBMV). In this study, genetic linkage analysis identified that the APN1¯ phenotype and the mutation in Cry1Ac-resistant segregated independently, although they were always associated under Cry1Ac selection. The mutation and APN1¯ phenotype were separated into two strains respectively.
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