Publications by authors named "J Ferrario"

Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel therapies and to establish the basis for personalized medicine. We conclude the viewpoint by a call to action to further improve interactions between clinician and basic scientists.

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The recreational boating sector is a major vector for the introduction of non-indigenous species (NIS) via biofouling. Despite applying control measures to prevent the growth of fouling communities, most vessels are NIS carriers. This study assessed the effectiveness of different antifouling strategies in a manipulative experiment by testing two common coating typologies (biocide-based and foul-release coatings), accompanied with simulated maintenance practices.

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Managing marine nonindigenous species (mNIS) is challenging, because marine environments are highly connected, allowing the dispersal of species across large spatial scales, including geopolitical borders. Cross-border inconsistencies in biosecurity management can promote the spread of mNIS across geopolitical borders, and incursions often go unnoticed or unreported. Collaborative surveillance programs can enhance the early detection of mNIS, when response may still be possible, and can foster capacity building around a common threat.

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Hull fouling is considered to be the most significant vector of introduction of marine non-indigenous species (NIS) in the Madeira Archipelago (NE Atlantic) because these islands provide a vital passage route for many ships. The transfer of species between boat hulls and artificial substrates in marinas is known to be high. Bryozoans are among the most common groups of marine invertebrates growing on this type of substrate.

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Article Synopsis
  • Tau is a protein important for neuron function and is linked to neurodegenerative diseases like Alzheimer's due to abnormal splicing of its gene, leading to an imbalance of tau protein isoforms (3R and 4R).
  • Research indicates that correcting this imbalance can serve as a potential therapy, with prior studies showing that local manipulation of tau splicing in young mice mitigates cognitive and motor deficits.
  • The current study explores whether similar splicing regulation can reverse tau-related impairments in older mice, using behavioral tests and imaging methods to evaluate effectiveness in preventing cognitive and motor declines associated with tauopathy.
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