Publications by authors named "J Fernandez-Torres"
Osteoarthritis (OA) is a chronic degenerative disease characterized by the progressive loss of articular cartilage. The role of cigarette smoke (CS) in OA is debated, with some studies suggesting a protective effect while others indicate it may pose a risk. Our preliminary findings suggest a link between smoking in young adults and severe knee OA, though the extent of this contribution is unclear.
View Article and Find Full Text PDFBackground: Diagnosing periprosthetic joint infection (PJI) remains a significant challenge for healthcare professionals. Commonly utilized inflammatory markers include erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cells (WBC). Human -defensin 1 (-defensin) is an antimicrobial peptide elevated in infection, yet its diagnostic value for PJI has not been explored.
View Article and Find Full Text PDFBackground: Deposition of calcium pyrophosphate (CPP) crystals is observed in most joints affected by severe osteoarthritis (OA). CPP may cause local damage by inducing an inflammatory process and oxidative stress (OS).
Objectives: To evaluate inflammation and OS induced by CPP deposition and their association with the degree of knee OA.
Article Synopsis
- Ankylosing spondylitis (AS) is an inflammatory disease impacting the spine and related areas, with possible extra-articular effects, and β-Defensins may influence the immune response in AS patients.* -
- The study focused on two gene variants (rs11362 and rs1800972) in Mexican AS patients, finding significant associations between certain genotypes and increased AS risk, as well as elevated inflammatory markers like CRP and ESR in specific genotype carriers.* -
- Results indicate that the DEFB1 gene is potentially crucial in the development of AS, highlighting the gene's interactions with factors such as sex.*
Background: Gouty arthritis is a metabolic disease characterized by the deposition of monosodium urate crystals in the joints, which triggers the release of interleukin-1β (IL-β) by activating the NLRP3 inflammasome. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor involved in IL-β production and as a regulator of NLRP3.
Objectives: The aims were to analyze the association of HIF1A rs11549465, rs11549467, and rs2057482 variants in patients with gouty arthritis, and to evaluate the correlation between urate and HIF-1α levels according to the associated genotypes.