Influence of atropine, pirenzepine and cimetidine on nocturnal gastro-intestinal motility and gastric acid secretion.

The present study was performed to investigate the correlation between gastric H-ion-concentration and interdigestive motility (1) under basal conditions and (2) under the influence of pirenzepine, atropine and cimetidine. During the control period 6.5 (DZ1 5, DZ9 12) MMC's per 12-hour periods (69 +/- 7% gastrointestinal MMC's) were recorded.

[Diagnosis of the irritable colon: manometric and myoelectric investigations (author's transl)].

Manometric investigations of patients with irritable colon show an undisturbed cyclic course of interdigestive motility studies of the rectosigmoid in patients with irritable colon show a spectrum of variable frequency of slow membrane potential changes with predominance of a frequency of 3/min. In addition, after a 1000 calorie test meal, patients with irritable colon showed a significantly prolonged increase of motility. As functional disturbances of irritable colon are mainly diagnosed by exclusion of organic changes, further development and rational use of colonic myoelectric methods promises future possibilities for objective diagnosis and control of treatment.

[Growth and metastasis of malignant tumors].

The high life expectancy of today seems to be an important factor for the increasing frequency of malignant disease, which is observed nowadays: the patient lives long enough to develop cancer. Increased knowledge about growth and spread of malignant tumors allows a better understanding of tumor pathogenesis and is a prerequisite for differentiated and effective therapy. Besides it is necessary to improve the early detection rate of cancer and to select and control high risk groups.