Publications by authors named "J Fedacko"
Purpose Fibromyalgia syndrome (FMS) presents a chronic pain condition affecting muscles and joints. Investigating circadian rhythms' disruption, integral to physiological responses, this study delves into the potential impact of gene polymorphism (rs57875989) on FMS pathogenesis. Methods In this study, we investigated gene polymorphism in 100 FMS patients and an equal number of control individuals.
View Article and Find Full Text PDFDespite increased availability of effective drug therapy for treatment of heart failure (HF), the morbidity and mortality in chronic heart failure (CHF) are unacceptably high. Therefore, there is an urgent need to ascertain new imaging techniques to identify early sub-clinical forms of cardiac dysfunctions, to guide early relevant treatment. It seems that all the behavioral risk factors-such as tobacco, alcoholism, Western-type diet, sedentary behavior and obesity, emotional disorders, and sleep disorder are associated with early cardiac dysfunction, which may be identified by speckle-tracking echocardiography (STE).
View Article and Find Full Text PDFDigital pathology has emerged as a revolutionary field, transforming traditional diagnostic practices by integrating advanced imaging technologies, computational tools, and artificial intelligence (AI). Adopting digital slides over conventional glass slides enables high-resolution imaging, facilitating remote consultations, second opinions, and telepathology. The digitalization of pathology laboratories enhances workflow efficiency and allows for large-scale data storage, retrieval, and analysis, paving the way for developing robust diagnostic algorithms.
View Article and Find Full Text PDFArticle Synopsis
- * Current guidelines emphasize that lower levels of low-density lipoprotein cholesterol (LDL-C) are better, advocating for early and aggressive treatment, including a variety of effective medications beyond just statins.
- * The International Lipid Expert Panel (ILEP) has published guidelines for optimizing LLT in post-ACS patients, highlighting the need for combination therapies and personalized care to improve adherence and treatment outcomes among high-risk individuals.
Article Synopsis
- The Western diet contributes to oxidative stress and inflammation, increasing the risk of cardiovascular diseases and type 2 diabetes, while the Mediterranean diet, rich in antioxidants, offers protective benefits.
- The production of molecular hydrogen in the gut, supported by fiber, flavonoids, and probiotics, acts as a powerful antioxidant, potentially reducing inflammation and oxidative stress.
- Recent studies suggest that both naturally produced and artificially administered molecular hydrogen have therapeutic effects in managing cardiovascular diseases and metabolic disorders, but further research is needed to confirm these findings on a larger scale.