Publications by authors named "J Farre"
The precise mode of action of ganaplacide (KAF156), a phase III antimalarial candidate, remains elusive. Here we employ omics-based methods with the closely related chemical analog, GNF179, to search for potential targets. Ranking potential targets derived from chemical genetics and proteomic affinity chromatography methodologies identifies , or Synthetic Enhancement of YOP1, which is predicted to encode an essential dynamin-like GTPase implicated in homotypic fusion of endoplasmic reticulum (ER) membranes.
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- Cells adjust their protein content in response to environmental changes through a combination of protein synthesis and degradation processes, particularly involving proteasomal and vacuolar pathways.
- Researchers developed a method using isotopically labeled nutrients to study protein degradation in yeast, revealing that bulk and selective autophagy are the main drivers of proteome remodeling.
- The study found that different types of autophagy, influenced by environmental signals, manage the breakdown of various proteins, and has created an online database to assist in identifying the proteins and pathways involved in this process.
Summary: perox-per-cell automates cumbersome, image-based data collection tasks often encountered in peroxisome research. The software processes microscopy images to quantify peroxisome features in yeast cells. It uses off-the-shelf image processing tools to automatically segment cells and peroxisomes and then outputs quantitative metrics including peroxisome counts per cell and spatial areas.
View Article and Find Full Text PDFautomates cumbersome, image-based data collection tasks often encountered in peroxisome research. The software processes microscopy images to quantify peroxisome features in yeast cells. It uses off-the-shelf image processing tools to automatically segment cells and peroxisomes and then outputs quantitative metrics including peroxisome counts per cell and spatial areas.
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