Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease.

Alzheimer's disease (AD) is gradually increasing in prevalence and the complexity of its pathogenesis has led to a lengthy process of developing therapeutic drugs with limited success. Faced with this challenge, we proposed using a state-of-the-art drug screening algorithm to identify potential therapeutic compounds for AD from traditional Chinese medicine formulas with strong empirical support. We developed four deep neural network (DNN) models for AD drugs screening at the disease and target levels.

Exploring the effects of supplementing monoterpenoids in based-diet in Improving the growth performance, feed efficiency, digestibility and body composition.

Monoterpenoids are interesting hydrocarbons typically found in essential oils and have a significant role in medicinal and biological purposes. The goal of this study was to investigate the effects of two monoterpenoids, carvacrol (CAR) and menthol (MEN), supplemented with leaf meal (MOLM) based diets on growth parameters, digestibility and body composition of Nile tilapia (). Alongside the basal diet (control-T1), nine experimental diets supplemented with categorized levels of CAR and MEN at 200, 300 and 400 mg/kg individually and their mixtures (MIX) (1:1) (CAR-T2, 200; T3, 300; T4, 400 mg/kg, MEN-T5, 200; T6, 300; T7, 400 mg/kg and MIX- (1:1) T8, 200; T9, 300; T10, 400 mg/kg) were fed to the fingerlings (6.

The global prevalence of emotional eating in overweight and obese populations: A systematic review and meta-analysis.

This systematic review aims to investigate the current prevalence of emotional eating and its associated factors in overweight and obese populations. We included studies that (1) reported prevalence of emotional eating; (2) were in the context of weight gain or overweight and obesity; (3) used a validated psychometric tool to assess emotional eating; (4) were published as an internationally referred journal article and (5) were reported in the English language. Articles were searched on eight electronic databases (CINAHL, EMBASE, PsychINFO, ProQuest, PubMed, Scopus, The Cochrane Library and Web of Science) from the journals' inception to 11 April 2024.