Publications by authors named "J F X Ainscough"
Unlabelled: Responding to climate change requires that people engage in different forms of climate citizenship. These span from individual consumption choices, to taking part in forms of collective action to steer the behaviour of governments and in the private sector. Here we analyse data from the Net Zero Diaries project to explore how attitudes to different forms of climate citizenship develop as people become more aware about the scale of societal change required to reach net zero carbon emissions by 2050.
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- CIZ1 is a protein that stabilizes epigenetic states, particularly in the inactive X chromosome of females, and its deletion in mice leads to hyperproliferation, indicating a link to various cancers.
- In CIZ1-null murine fibroblasts, there is reduced H4K20me1, resulting in compromised nuclear condensation when entering a resting state, affecting genes related to DNA repair despite overall transcriptional repression being maintained.
- The study highlights the critical role of CIZ1 in maintaining chromatin structure during quiescence cycles, with its absence leading to genome instability, making cells more vulnerable to damage and potential transformation into cancerous colonies.
CIZ1 forms large assemblies at the inactive X chromosome (Xi) in female fibroblasts in an Xist lncRNA-dependent manner and is required for accurate maintenance of polycomb targets genome-wide. Here we address requirements for assembly formation and show that CIZ1 undergoes two direct interactions with Xist, via independent N- and C-terminal domains. Interaction with Xist, assembly at Xi, and complexity of self-assemblies formed in vitro are modulated by two alternatively spliced glutamine-rich prion-like domains (PLD1 and 2).
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- Epithelial tissues serve as crucial barriers that interact with harmful pathogens and harmless microbes, requiring them to effectively sense and respond to these entities.
- The cytokine interleukin-36γ (IL-36γ) functions as a key player in distinguishing between harmful pathogens and harmless microbes based on cell damage and proteolytic activation.
- IL-36γ is released and activated in response to damage caused by pathogens, making it essential for initiating immune responses and inflammation in epithelial tissues.
Background: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the relevance of Orai1 is still unclear.
Methods: To test the role of these Orai1 channels in the cardiac pathophysiology, a transgenic mouse was generated with cardiomyocyte-specific expression of an ion pore-disruptive Orai1 mutant (C-dnO1).