Publications by authors named "J F Willett"
Insights into ecology, pathogenesis, and biofilm formation of from functional genomics.
Microbiol Mol Biol Rev
December 2024
SUMMARY is a significant resident of the gastrointestinal tract of most animals, including humans. Although generally non-pathogenic in healthy hosts, this microbe is adept at the exploitation of compromises in host immune functions, resulting in life-threatening opportunistic infections whose treatments are complicated by a high degree of intrinsic and acquired resistance to antimicrobial chemotherapy. Historically, progress in enterococcal research was limited by a lack of experimental models that replicate natural infection pathways and the relevance of studies to the natural biology of the organism.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to validate a 12-station OSCE designed for assessing clinical competence in undergraduate nursing students.
- A sample of 65 senior nursing students participated, showing statistically significant interrater reliability and establishing content validity for the OSCE checklist and stations.
- While students found the OSCE helpful, they also expressed feelings of unpreparedness, and there were no significant correlations between OSCE scores and final course grades.
is a commensal bacterium in the gastrointestinal (GI) tract of humans and other organisms. also causes infections in root canals, wounds, the urinary tract, and on heart valves. metabolizes arginine through the arginine deiminase pathway, which converts arginine to ornithine and releases ATP, ammonia, and CO.
View Article and Find Full Text PDFArticle Synopsis
- Alzheimer's disease is a leading form of dementia in older adults, and early detection is crucial for effective intervention since its effects can begin decades before symptoms show.
- The study utilized advanced machine learning techniques to create models predicting Alzheimer's status and onset age, analyzing a range of biological and medical data from UK Biobank, with significant emphasis on the importance of specific proteins.
- Notable findings include that GFAP and CXCL17 proteins are strong predictors of Alzheimer's, while genomics and proteomics provided the most valuable information in predicting disease status, although expanding the dataset with "AD-by-proxy" cases didn't enhance prediction accuracy.
Article Synopsis
- Alzheimer's disease (AD) is the most common form of dementia, and while many genetic factors have been found, research has mostly focused on people of European descent.
- This study analyzed whole genome sequencing data from a diverse group of participants (about 49,000 AD cases and 383,000 controls) to identify new genetic loci associated with AD.
- The researchers discovered 16 novel loci linked to clinically-diagnosed AD and AD-by-proxy, emphasizing the need for more diverse studies in genetic research.