SARS-CoV-2 IgG antibodies in COVID-19 convalescent plasma and conventional plasma units.

Background: The Association for the Advancement of Blood and Biotherapies guidelines recommend the use of high-titer COVID-19 convalescent plasma (CCP) for patients with SARS-CoV-2 at high risk of disease progression, including those who are immunocompromised. We hypothesized that conventional plasma units have comparable neutralizing antibody levels to CCP.

Study Design And Methods: Conventional plasma and CCP units were obtained from blood suppliers.

Observation of magnetic skyrmion lattice in CrMnGe by small-angle neutron scattering.

Incommensurate magnetic phases in chiral cubic crystals are an established source of topological spin textures such as skyrmion and hedgehog lattices, with potential applications in spintronics and information storage. We report a comprehensive small-angle neutron scattering (SANS) study on the B20-type chiral magnet Cr[Formula: see text]Mn[Formula: see text]Ge, exploring its magnetic phase diagram and confirming the stabilization of a skyrmion lattice under low magnetic fields. Our results reveal a helical ground state with a decreasing pitch from 40 to 35 nm upon cooling, and a skyrmion phase stable in applied magnetic fields of 10-30 mT, and over an unusually wide temperature range for chiral magnets of 6 K ([Formula: see text], [Formula: see text] K).

Intestinal histoplasmosis with granulomatous colonic and mesenteric lymphadenitis due to Histoplasma mississippiense infection in an American Mammoth Jackstock donkey (Equus asinus).

Histoplasmosis is a rarely reported clinical disease of equids in North America and is historically attributed to Histoplasma capsulatum var. capsulatum. This report details a case of intestinal histoplasmosis with lymphadenitis in an American Mammoth Jackstock donkey from Mississippi.

Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus.

The basal ganglia (BG) are an evolutionarily conserved and phylogenetically old set of sub-cortical nuclei that guide action selection, evaluation, and reinforcement. The entopeduncular nucleus (EP) is a major BG output nucleus that contains a population of GABA/glutamate cotransmitting neurons (EP) that specifically target the lateral habenula (LHb) and whose function in behavior remains mysterious. Here, we use a probabilistic switching task that requires an animal to maintain flexible relationships between action selection and evaluation to examine when and how GABA/glutamate cotransmitting neurons contribute to behavior.