The association between fluoride concentrations and spontaneous humeral fracture in first-lactation dairy cows: results from two New Zealand studies.

Aim: To assess whether the fluoride concentration in the humeri of first-lactation, 2-year-old dairy cows with a spontaneous humeral fracture is significantly different from that of first-lactation, 2-year-old dairy cows without a humeral fracture.

Methods: Two studies were conducted, the first with nine bone samples from 2-year-old, first-calving dairy cows with a humeral fracture (all from the Waikato region) age-matched with seven control bone samples from the Waikato, Bay of Plenty and Manawatū-Whanganui regions. The second study used 26 bone samples from 2-year-old, first-lactation dairy cows with a humeral fracture (from the Otago, Canterbury, Southland, West Coast, Waikato and Manawatū-Whanganui regions) age-matched with 14 control bone samples (all from the Manawatū-Whanganui region or unknown).

Targeted CRISPR regulation of ZNF865 enhances stem cell cartilage deposition, tissue maturation rates, and mechanical properties in engineered intervertebral discs.

Cell and tissue engineering based approaches have garnered significant interest for treating intervertebral disc degeneration and associated low back pain due to the substantial limitations of currently available clinical treatments. Herein we present a clustered regularly interspaced short palindromic repeats (CRISPR)-guided gene modulation strategy to improve the therapeutic potential of cell and tissue engineering therapies for treating intervertebral disc disease. Recently, we discovered a zinc finger (ZNF) protein, ZNF865 (BLST), which is associated with no in-depth publications and has not been functionally characterized.

Collaborative Development of a Farm Systems Learning Platform "4D Virtual Farm".

Over the past 20 years, a lower percentage of veterinary and animal science students entering Australian and New Zealand schools have a background or ongoing contact with livestock production systems. The increasing use of digital technologies over the same time provides a practical option to introduce students to the seasonal operations on livestock farms. This article describes the development of the 4D Virtual Farm, established to showcase 11 representative livestock farms across Australasia allowing students to virtually travel through seasons and place over each farming enterprise.

Quasi-periodic X-ray eruptions years after a nearby tidal disruption event.

Quasi-periodic eruptions (QPEs) are luminous bursts of soft X-rays from the nuclei of galaxies, repeating on timescales of hours to weeks. The mechanism behind these rare systems is uncertain, but most theories involve accretion disks around supermassive black holes (SMBHs) undergoing instabilities or interacting with a stellar object in a close orbit. It has been suggested that this disk could be created when the SMBH disrupts a passing star, implying that many QPEs should be preceded by observable tidal disruption events (TDEs).

A NOVEL FOUR-POINT SCLERAL FIXATION TECHNIQUE WITH A HYDROPHOBIC INTRAOCULAR LENS: The Loop to Optic and Trailing end to Outside Technique.

Purpose: To describe a new surgical technique that combines four-point, flanged polypropylene scleral fixation with a hydrophobic intraocular lens (IOL).

Methods: Using the Envista MX60 and 6.0 polypropylene, scleral four-point fixation was achieved using a flanged-suture technique five times in a model eye and in a case series of eight patients, retrospectively reviewed.