Publications by authors named "J F Tuohy"
Article Synopsis
- A study explored the use of high-frequency irreversible electroporation (H-FIRE) as a new treatment for primary lung tumors in dogs, which is a less invasive method that destroys cancer cells by creating nanopores in their membranes.
- Five canine patients received H-FIRE treatment prior to surgical tumor removal, with results showing evidence of tumor ablation through histological analysis and specific staining techniques to identify cell death.
- The treatment was generally well tolerated, and initial findings indicate that H-FIRE may positively affect the tumor immune microenvironment and gene expression related to immunity.
Here, we present a complete genome of KR-87, a biofilm-producing mesophile from the Arizonan Sonoran Desert. The sequence, assembled using Oxford Nanopore Technologies' long-read sequencing platform, predicts a genome size of 4.78 Mbp, with 6 replicons, 4,361 protein-coding genes, and a G+C content of 69.
View Article and Find Full Text PDFObjective: To report the clinical characteristics, treatments, and outcomes in a cohort of dogs with histologically confirmed retroperitoneal sarcoma (RPS) and to identify potential variables of prognostic significance.
Animals: 46 client-owned dogs from 10 clinics with histopathologic diagnosis of a sarcoma originating from the retroperitoneal space.
Methods: Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes.
Background: Osteosarcoma (OS) is the most frequently occurring primary bone tumor in dogs and people and innovative treatment options are profoundly needed. Histotripsy is an emerging tumor ablation modality, and it is essential for the clinical translation of histotripsy to gain knowledge about the outcome of nonablated tumor cells that could remain postablation. The objective of this study was to characterize the cell death genetic signature and proliferation response of canine OS cells post a near complete histotripsy ablation (96% ± 1.
View Article and Find Full Text PDFCancer is a devasting disease resulting in millions of deaths worldwide in both humans and companion animals, including dogs. Treatment of cancer is complex and challenging and therefore often multifaceted, as in the case of osteosarcoma (OS) and soft tissue sarcoma (STS). OS predominantly involves the appendicular skeleton and STS commonly develops in the extremities, resulting in treatment challenges due to the need to balance wide-margin resections to achieve local oncological control against the functional outcomes for the patient.
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