Publications by authors named "J F Sturgill"
Article Synopsis
- A cardiac septal occluder (CSO) can be used endoscopically to treat tracheoesophageal fistula (TEF), particularly in complex cases.
- This case study discusses a patient with metastatic cervical cancer who developed a malignant TEF due to direct invasion of the trachea, despite prior treatment with radiotherapy and stenting.
- The use of a PFO occluder as a palliative measure effectively closed the TEF, helping to prevent aspiration pneumonia and enhance the patient's quality of life.
Metabolism research is increasingly recognizing the contributions of organelle crosstalk to metabolic regulation. Mitochondria-associated membranes (MAMs), which are structures connecting the mitochondria and endoplasmic reticulum (ER), are critical in a myriad of cellular functions linked to cellular metabolism. MAMs control calcium signaling, mitochondrial transport, redox balance, protein folding/degradation, and in some studies, metabolic health.
View Article and Find Full Text PDFOn December 8th 2023, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. The 2023 meeting focused broadly on how acute and chronic alcohol exposure leads to immune dysregulation, and how this contributes to damage in multiple tissues and organs. These include impaired lung immunity, intestinal dysfunction, autoimmunity, the gut-Central Nervous System (CNS) axis, and end-organ damage.
View Article and Find Full Text PDFProtein S (PS), the critical plasma cofactor for the anticoagulants tissue factor (TF) pathway inhibitor (TFPI) and activated protein C (APC), circulates in two functionally distinct pools: free (anticoagulant) or bound to complement component 4b-binding protein (C4BP) (anti-inflammatory). Acquired free PS deficiency is detected in several viral infections, but its cause is unclear. Here, we identified a shear-dependent interaction between PS and von Willebrand Factor (VWF) by mass spectrometry.
View Article and Find Full Text PDFArticle Synopsis
- Elevated levels of plasminogen activator inhibitor type 1 (PAI-1) are linked to worse outcomes in sepsis, including increased mortality and kidney injury.
- In a study using a sepsis model in mice, researchers found that older mice lacking PAI-1 were more susceptible to sepsis than those with PAI-1, while younger mice showed no significant difference in survival based on PAI-1 presence.
- The findings suggest that PAI-1 plays a crucial role in protecting older individuals from severe sepsis and related kidney damage, indicating that age is an important factor in sepsis outcomes.