Publications by authors named "J F Quarleri"
Intra-host diversity is an intricate phenomenon related to immune evasion, antiviral resistance, and evolutionary leaps along transmission chains. SARS-CoV-2 intra-host variation has been well-evidenced from respiratory samples. However, data on systemic dissemination and diversification are relatively scarce and come from immunologically impaired patients.
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- - The review examines the connection between mitochondrial dysfunction, aging, and obesity in relation to COVID-19, highlighting how these factors can worsen the disease's severity.
- - Mitochondria play a crucial role in energy production and cellular resilience, and their decline with age and in obesity compromises the body's antiviral responses.
- - The study suggests that understanding mitochondrial health could open up new treatment strategies for managing severe COVID-19 outcomes and long-term effects, known as long COVID.
Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent effects on bone tissue homeostasis. Our findings suggest that MSCs and osteoblasts are susceptible to R5- and X4-tropic HIV but do not support productive HIV replication.
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- COVID-19 may affect disease progression in people living with HIV, including those on effective treatment, by using chronic conditions related to HIV latency.
- Certain pro-inflammatory cytokines, elevated during SARS-CoV-2 infection, could reactivate latent HIV in infected cells.
- Research indicates that exposure to SARS-CoV-2 can reverse the latent state of HIV-1-infected cells and influence macrophage polarization, potentially increasing HIV production.
This study aims to explore the influence of coinfection with HCV and HIV on hepatic fibrosis. A coculture system was set up to actively replicate both viruses, incorporating CD4 T lymphocytes (Jurkat), hepatic stellate cells (LX-2), and hepatocytes (Huh7.5).
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