Publications by authors named "J F Pineau"
Article Synopsis
- Tumor-infiltrating memory T cell subpopulations in non-small cell lung cancer (NSCLC) can be categorized based on various surface markers, with CD103 often used but not universally expressed.
- In studies, multiparametric cytometry and multiplex immunofluorescence techniques were applied to analyze T-cell behavior in vaccinated mice and human NSCLC patients, revealing distinct subpopulations and their impact on clinical outcomes.
- Results showed that a specific double-positive T cell subset (CD103+CD49a+) was more functional than a single-positive subset (CD49a+), with implications for predicting responses to immunotherapy, particularly relating to PD-1 treatment.
We provide a comprehensive study of the coordination of with palladium(II), including presentation of a novel bifunctional analogue, bearing an aniline pendant. The complexation of palladium(II) with was examined by various techniques, including NMR analysis and potentiometric titrations which revealed that the Pd(II) complex can adopt different configurations such as -I and -III. In addition, forms a thermodynamically stable palladium(II) complex, the stabilization being attributed to the deprotonation of the amide function.
View Article and Find Full Text PDFAsteroids with diameters less than about 5 km have complex histories because they are small enough for radiative torques (that is, YORP, short for the Yarkovsky-O'Keefe-Radzievskii-Paddack effect) to be a notable factor in their evolution. (152830) Dinkinesh is a small asteroid orbiting the Sun near the inner edge of the main asteroid belt with a heliocentric semimajor axis of 2.19 AU; its S-type spectrum is typical of bodies in this part of the main belt.
View Article and Find Full Text PDFAlterations in neurometabolism and mitochondria are implicated in the pathophysiology of psychiatric conditions such as mood disorders and schizophrenia. Thus, developing objective biomarkers related to brain mitochondrial function is crucial for the development of interventions, such as central nervous system penetrating agents that target brain health. Lactate, a major circulatory fuel source that can be produced and utilized by the brain and body, is presented as a theranostic biomarker for neurometabolic dysfunction in psychiatric conditions.
View Article and Find Full Text PDFHospital-based health technology assessment of innovative medical devices: insights from a nationwide survey in France.
Int J Technol Assess Health Care
September 2023
Objectives: To better understand the process of hospital acquisition of innovative medical devices (MDs) and the hospital-based health technology assessment (HB-HTA) pathways in France, an in-depth study based on a quantitative approach is needed. The aim of the present study was to assess through a national survey how HB-HTA is currently implemented in French hospitals and to identify its level of formalization.
Methods: A quantitative online survey was conducted among hospitals performing HB-HTA in France, with a focus on the acquisition of innovative MDs for individual use.