Publications by authors named "J F Passos"
Senescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their expression. We identified the mitochondrial citrate carrier (SLC25A1) and ATP-citrate lyase (ACLY) as critical for this process.
View Article and Find Full Text PDFBackground: Neurofibromatosis type 1 (NF1) is a common genetic disorder of phenotypic variability with age-dependent penetrance. This study describes the diagnosis, clinical characterization, management, and outcomes of a large patient cohort with plexiform neurofibroma (PN) treated with selumetinib in a real-world clinical setting.
Methods: This single-center observational study consecutively enrolled patients with NF1-PN treated with selumetinib from April 2018 to 2023.
Article Synopsis
- Ascaridoidea is a superfamily of nematodes that includes gastrointestinal parasites affecting various vertebrates, with origins tracing back to the Carboniferous period.
- * Recent findings from the Tremembé Formation in Brazil have provided fossilized bird coprolites containing preserved Ascaridoidea eggs, specifically showing early embryonic development stages.
- * The discovery highlights the ecological interactions between piscivorous birds and nematodes, indicating that ancient Brazilian environments supported the evolution of these parasites during the Paleogene period.
Article Synopsis
- Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
- The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
- The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
Article Synopsis
- Scientists studied how old skin cells, called senescent cells, can make other parts of the body age faster too!
- They found that adding these old skin cells to young mice made them weaker and affected how well they could move around, as well as their thinking skills.
- This suggests that old skin cells might be spreading aging effects to other organs, like the brain, which could explain why aging can be linked to problems in both the skin and brain.