Mixed-methods analysis of personal growth in an equity-centered leadership development program.

Introduction: Self-efficacy (or the belief in one's ability to effect change) often moderates the relationship between education, interest, and actions in evaluations of training programs that prepare community-based investigators in the clinical and translational sciences workforce. Such evaluations, however, tend to emphasize individual-level attitudes when there are also community- or organizational-level outcomes impacted.

Methods: This study uses a novel sequential, explanatory mixed-methods design to explore multiple levels of self-efficacy (or self-awareness of personal growth in leadership) in the Clinical Scholars program, an equity-centered leadership development program for mid- to later-career healthcare professionals.

Sensitivity of a vector atomic magnetometer based on electromagnetically induced transparency.

We present a realization of a magnetic sensor based on electromagnetically induced transparency (EIT) resonances observed in hot Rb vapor using lin∥lin polarized dichromatic light and evaluate scalar and vector capabilities of the sensor for measuring Earth-like magnetic fields. We demonstrate scalar measurement sensitivity of 2 / in the 1-100 Hz spectral frequency band using a ~1 cm Rb vapor cell, significantly improving the performance for such a configuration if compared with earlier measurements of large magnetic fields. By using a single linearly polarized dichromatic optical field, we are also able to determine the direction of the magnetic field with respect to the light propagation direction and polarization, taking advantage of the symmetries of the interaction scheme.

The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp.

Cell division is a key step in the bacterial lifecycle that must be appropriately regulated to ensure survival. This work identifies the alarmone (p)ppGpp (ppGpp) as a general regulator of cell division, extending our understanding of the role of ppGpp beyond a signal for starvation and other stress. Even in nutrient-replete conditions, basal levels of ppGpp are essential for division to occur appropriately and for cell size to be maintained.

SARS-CoV-2 infection establishes a stable and age-independent CD8 T cell response against a dominant nucleocapsid epitope using restricted T cell receptors.

The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8 T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8 T cells targeting non-spike protein of SARS-CoV-2 before and after infection remains incomplete. Here, we analyzed CD8 T cells recognizing six epitopes from the SARS-CoV-2 nucleocapsid (N) protein and found that SARS-CoV-2 infection slightly increased the frequencies of N-recognizing CD8 T cells but significantly enhanced activation-induced proliferation compared to that of the uninfected donors.

Technical limits of sensitivity for EIT magnetometry.

Optical magnetometers based on electromagnetically induced transparency (EIT) in atomic vapor can in principle achieve outstanding sensitivity and accuracy in a small volume. Up until now, however, the predicted fundamental quantum-noise-limited sensitivity has not been achieved in practice due to various technical limitations associated with the measurement apparatus. Here we analyze these restrictions and propose viable mitigation strategies for performance optimization.