Publications by authors named "J F Mantovani"

•Durability is vital for transcatheter aortic valve replacement in younger patients.•Aortic insufficiency is one of the features of structural valve degeneration.•Degenerated ACURATE neo can be treated with low implantation of an oversized Myval.

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  • As of May 16, 2020, Brazil has reported 233,142 COVID-19 cases and 15,633 deaths, with São Paulo State being the most affected region, having over 60,000 cases.
  • Researchers analyzed the spatial distribution of COVID-19 in São Paulo City and its surrounding areas, finding that the city is a significant hotspot for cases and deaths, while other areas are less impacted.
  • The study revealed a complex relationship between death rates, population density, and hospital beds, suggesting that actual patient conditions play a critical role in fatalities, and highlighted the effectiveness of social distancing measures in controlling the virus spread.
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Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae.

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  • * Researchers identified 32 individuals with microcephaly, neurodevelopmental issues, and other neurological symptoms due to mutations in NARS1, revealing reduced levels of NARS1 mRNA and enzyme activity in affected cells.
  • * The study suggests that these mutations lead to neurodevelopmental diseases through mechanisms like toxic gain-of-function for new mutations and partial loss-of-function for recessive mutations.
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The collapse of the Fundão dam in Mariana, MG, in 2015 resulted in the overflow of more than 50 million m of mud containing mine tailings, leaving a path of destruction and immeasurable social and environmental consequences. Tailings' chemical and physical assessments revealed the presence of some elements at levels higher than those allowed by Brazilian guidelines. The tailings also showed high density, which restricts vegetation recovery.

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