Publications by authors named "J F Linzer"
Article Synopsis
- RNA research is expanding, but understanding its structural dynamics and interactions with small molecules remains limited, especially when compared to protein studies.
- This study focuses on addressing the weak CH···O interactions in RNA, which are significant yet often overlooked in force field development, particularly in widely used Amber RNA force fields.
- By adjusting the CH···O repulsion in these force fields, the study found that RNA simulations became more stable, resulting in improved accuracy in modeling RNA structures during molecular dynamics simulations.
Article Synopsis
- - RNA molecules can form different structures, and stem-loops are a common one; this study analyzed 15 RNA stem-loop sequences using molecular dynamics simulations.
- - The analysis revealed that the stem regions generally adopt a stable A-form structure, but the loop regions are more variable and require adjustments for accurate modeling.
- - Current models for simulating RNA are still challenging, but the findings from this study could serve as a benchmark for testing new RNA modeling techniques in the future.
Receptor tyrosine kinases (RTKs) can show extensive crosstalk, directly and indirectly. Elucidating RTK crosstalk remains an important goal in the clinical combination of anti-cancer therapies. Here, we present mass spectrometry and pharmacological approaches showing the hepatocyte growth factor receptor (MET)-promoting tyrosine phosphorylation of the epidermal growth factor receptor (EGFR) and other membrane receptors in MET-amplified H1993 NSCLC cells.
View Article and Find Full Text PDFBackground: The International Classification of Diseases (ICD) has been grouping the allergic and hypersensitivity disorders involving the respiratory tract under topographic distribution, regardless of the underlying mechanisms, triggers or concepts currently in use for allergic and hypersensitivity conditions. In order to strengthen awareness and deliberate the creation of the new "Allergic or hypersensitivity disorders involving the respiratory tract" section of the ICD-11, we here propose make the building process public.
Methods: The new frame has been constructed to cover the gaps previously identified and was based on consensus academic reports and ICD-11 principles.
Article Synopsis
- - The Medicare Resource-Based Relative Value Scale (RBRVS) is the main way that most U.S. payers determine physician payments, influencing both public and private compensation systems.
- - Many healthcare practices, especially large ones, use RBRVS to measure physician productivity which can impact how much doctors are paid.
- - There are concerns that RUC surveys used to value services may undervalue nonprocedural services, prompting the American Academy of Pediatrics to advocate for fair evaluations to ensure pediatricians are appropriately compensated.