Publications by authors named "J F Landrier"
A comprehensive analysis of the impact of high-intensity interval vs. moderate-intensity continuous training on global and regional myocardial function in patients early after acute myocardial infarction - the STRAICT randomized controlled trial.
Eur J Prev Cardiol
March 2025
Aims: To compare the effect of moderate-intensity continuous training (MICT) vs. isovolumic high-intensity interval training (HIIT) on left ventricular (LV) myocardial function early post acute myocardial infarction (AMI). Training-induced changes were analyzed at both global and segmental levels using advanced deformation echocardiographic imaging techniques.
View Article and Find Full Text PDFInflammation of adipose tissue is a contributing factor to many chronic diseases associated with obesity. We previously showed that micronutrients such as vitamin D (VD) limited this metabolic inflammation by decreasing inflammatory markers expression including miR-155 (microRNA-155) or miR-146a in different in vitro and in vivo models. These miRNAs could be incorporated into extracellular vesicles (EVs) in order to modulate the activity of target cells.
View Article and Find Full Text PDFArticle Synopsis
- This study looks into why obese individuals may have low vitamin E (VE) levels, specifically whether it's due to issues with how VE is absorbed in the intestines.
- After 12 weeks of a high-fat diet, mice showed increased weight and fat levels compared to those on a control diet, but surprisingly, they had higher levels of α-tocopherol (a form of vitamin E) in their blood and liver.
- The results suggest that even with obesity, these mice actually absorb vitamin E more effectively rather than having impaired absorption.
Background: Adipose tissue vitamin A (VA), that is, mainly retinol (RET) and its esters, comes from preformed VA and proVA carotenoids present in our food. Adipose tissue VA acts as hormonal cue maintaining essential aspects of adipocyte biology, which includes fat mobilization and catabolism, energy balance, and glucose homeostasis, and it is thus of particular interest to study its determinants, including genetic ones.
Objectives: This study aimed to identify genetic variations associated with adipose tissue VA concentration.
Article Synopsis
- * Researchers analyzed α-TOC concentrations in fasting plasma and adipose tissue from 42 healthy male participants, finding significant variability in adipose tissue α-TOC levels but no correlation with fasting plasma levels.
- * A model using 10 specific genetic variations (SNPs) explains 60% of the differences in adipose tissue α-TOC concentration, suggesting that genetics play a role in how the body stores and processes this vitamin. *