Towards Preventing Gaps in Health Care Systems through Smartphone Use: Analysis of ARKit for Accurate Measurement of Facial Distances in Different Angles.

There is a growing consensus in the global health community that the use of communication technologies will be an essential factor in ensuring universal health coverage of the world's population. New technologies can only be used profitably if their accuracy is sufficient. Therefore, we explore the feasibility of using Apple's ARKit technology to accurately measure the distance from the user's eye to their smartphone screen.

Introducing a Navigation Algorithm for Reducing the Spread of Diseases in Public Transport Networks.

Reducing passenger flow through highly frequented bottlenecks in public transportation networks is a well-known urban planning problem. This issue has become even more relevant since the outbreak of the SARS-CoV-2 pandemic and the necessity for minimum distances between passengers. We propose an approach that allows to dynamically navigate passengers around dangerously crowded stations to better distribute the passenger load across an entire urban public transport network.

Interaction of the retinal G-protein transducin with uracil nucleotides.

Little is known about the interaction of pyrimidine nucleotides with G-proteins. Here we report that under experimental conditions that exclude transphosphorylation reactions, nucleoside 5'-triphosphates inhibited transducin-catalyzed GTP hydrolysis in the order of potency guanosine 5'-[gamma-thio]triphosphate > GTP > guanosine 5'-[beta,gamma-imido]triphosphate > uridine 5'-[gamma-thio]triphosphate > UTP > CTP. Nucleoside 5'-diphosphates inhibited GTP hydrolysis in the order of potency GDP approximately guanosine 5'-[beta-thio]thiodiphosphate > uridine 5'-[beta-thio]diphosphate >> UDP (no effect).

Nucleoside diphosphate kinase activity in soluble transducin preparations biochemical properties and possible role of transducin-beta as phosphorylated enzyme intermediate.

Known nucleoside diphosphate kinases (NDPKs) are oligomers of 17-23-kDa subunits and catalyze the reaction N1TP + N2DP --> N1DP + N2TP via formation of a histidine-phosphorylated enzyme intermediate. NDPKs are involved in the activation of heterotrimeric GTP-binding proteins (G-proteins) by catalyzing the formation of GTP from GDP, but the properties of G-protein-associated NDPKs are still incompletely known. The aim of our present study was to characterize NDPK in soluble preparations of the retinal G-protein transducin.

The natural beta-carbolines facilitate inositol phosphate accumulation by activating small G-proteins in human neuroblastoma cells (SH-SY5Y).

The naturally occurring beta-carbolines exert psychotropic actions in humans and have numerous behavioral effects in animals. The known in vitro activities of these substances do not provide a satisfactory explanation for their in vivo effects. The present study was undertaken to explore the possibility of a specific signal transduction pathway.