Globalization of clinical trials in oncology: a worldwide quantitative analysis.

Background: Over the past two decades, the globalization of oncology clinical trials has expanded, yet significant disparities persist across countries. This study aimed to evaluate these geographical inequalities, the evolution of trial phases, and the adherence to ethical standards according to the World Bank's income group.

Materials And Methods: The ClinicalTrials.

Size-Up, Size-Down: Accuracy of Component Sizing with Computerized Tomography and Robotic-Assisted Total Knee Arthroplasty.

Templating prior to total knee arthroplasty (TKA) can help to improve surgical efficiency and potentially improve alignment and outcomes. The purpose of this article is to evaluate the ability of computed tomography (CT)-based preoperative templating to accurately predict implant sizes. A total of 724 Stryker MAKO robotic-assisted TKA cases were retrospectively evaluated from a prospectively collected database between January 2020 and October 2023.

Stereotype Threat at Work: A Meta-Analysis.

Stereotype threat refers to the concern of being judged based on stereotypes about one's social group. This preregistered meta-analysis examines the correlates of stereotype threat in the workplace ( = 61 independent samples, 40,134). Results showed that stereotype threat was positively related to exhaustion, identity separation, negative affect, turnover intentions, and behavioral coping, and negatively related to career aspirations, job satisfaction, organizational commitment, job engagement, job performance, positive affect, self-efficacy, and work authenticity.

Examining Negativity Biases in Facial Emotion Reactions in Young Persons First-Presenting with Borderline Personality Disorder.

Introduction: Individuals with borderline personality disorder (BPD) are thought to experience specific biosocial vulnerabilities that give rise to a maladaptive negativity bias in the perception and expression of emotions. However, while this negative bias has been identified in adults with full threshold BPD or high BPD features, it is unclear whether it is evident earlier in the course of the disorder-that being, young persons with first presentation BPD meeting three or more BPD features, as defined by early intervention models.

Methods: The current study compared patterns of facial responding in individuals aged 15-25 first presenting to a specialist outpatient service with three or more BPD features (n = 32) to age-matched healthy controls (n = 46).

Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank.

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide Protein Data Bank (wwPDB, wwPDB.org) data center for the global PDB archive, provides access to the PDB data via its RCSB.