Publications by authors named "J F Heijmans"
Background: Relapsed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) are associated with a poor prognosis. It is unknown which re-induction therapy provides the highest chance of durable remission. Commonly used therapies are high dose cytarabine (HiDAC) and triple therapy consisting of fludarabine, cytarabine, and idarubicin combined with granulocyte colony-stimulating factor (FLAG-IDA).
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- Chronic airway inflammation can lead to conditions like COPD and asthma, causing issues such as goblet cell hyperplasia and obstructed airflow in chronic bronchitis.
- Traditional animal testing methods are being replaced by in vitro three-dimensional cultures, but these often miss important characteristics of the human airway structure.
- The Bronchus-on-a-Chip (BoC) system was developed to create a more accurate model of bronchial epithelium, successfully mimicking human responses to inflammation and improving the testing of chronic airway conditions.
Endoplasmic reticulum (ER) stress and the adaptive response that follows, termed the unfolded protein response (UPR), are crucial molecular mechanisms to maintain cellular integrity by safeguarding proper protein synthesis. Next to being important in protein homeostasis, the UPR is intricate in cell fate decisions such as proliferation, differentiation, and stemness. In the intestine, stem cells are critical in governing epithelial homeostasis and they are the cell of origin of gastrointestinal malignancies.
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