Publications by authors named "J F Hacker"
Mast cells (MCs) expressing a distinctive protease phenotype (MCTs) selectively expand within the epithelium of human mucosal tissues during type 2 (T2) inflammation. While MCTs are phenotypically distinct from subepithelial MCs (MCTCs), signals driving human MCT differentiation and this subset's contribution to inflammation remain unexplored. Here, we have identified TGF-β as a key driver of the MCT transcriptome in nasal polyps.
View Article and Find Full Text PDFThe development of next-generation battery technologies needs to consider their environmental impact throughout the whole cycle life, which has brought new chemistries based on earth-abundant elements into the spotlight. Rechargeable calcium batteries are such an emerging technology, which shows the potential to provide high cell voltage and high energy density close to lithium-ion batteries. Additionally, the use of Ca as a charge carrier renders significant sustainable values.
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- Astrocyte-secreted signals play a crucial role in neurodegenerative diseases, but the impact of proinflammatory cytokines like IL-1α, TNF-α, and C1q on these signals is not well understood.
- In our study, we discovered that these cytokines significantly reduced the secretion of astrocyte exosomes (A-Exo.) and their distribution in SOD1G93A mice, a model for amyotrophic lateral sclerosis (ALS).
- Despite A-Exo. being non-toxic to motor neurons, they provided neuroprotection against excitotoxicity, which was hindered by cytokines and SOD1G93A expression, indicating a loss-of-function mechanism in their
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- * Between July 2023 and January 2024, California reported six RMSF cases linked to exposure in Tecate, Mexico, raising concerns as it was previously not identified as a high-risk area, and three of these cases were fatal.
- * Effective detection of RMSF cases necessitated collaborative efforts among various public health agencies, highlighting the need for increased awareness among healthcare providers to enable quicker diagnoses and treatments on both sides of the U.S.-Mexico border.
The etiologic agent of Pacific Coast tick fever (PCTF), a moderately severe tickborne illness that resembles Rocky Mountain spotted fever (RMSF), was first isolated in 1966 from specimens of Dermacentor occidentalis (the Pacific Coast tick) obtained in California. For several decades, this bacterium was identified ambiguously as the unclassified spotted fever group Rickettsia species 364-D, Rickettsia 364, or Rickettsia philipii. However, none of these epithets satisfied criteria of formal bacterial nomenclature.
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