Is Bone Marrow Trephine Biopsy Necessary in Multiple Myeloma Patients at Diagnosis?

Multiple myeloma (MM) diagnosis requires ≥10% plasma cell (PC) infiltration in the bone marrow (BM), detected by bone marrow aspiration (BMA) or biopsy (BMB). We evaluated the concordance of these 2 techniques in 189 patients. In 43 cases (23%), the techniques were discordant, 10 due to poor sample quality.

Use of Multimodal Imaging for Diagnosis and Management of Pulmonary Artery Sarcoma Mimicking as Acute Pulmonary Embolism.

Pulmonary artery sarcoma is a rare intravascular tumor that mimics pulmonary embolus. Early recognition and referral to surgery is important because nonsurgically treated tumors have a poor prognosis. Here, we describe a case of pulmonary artery sarcoma diagnosed with multimodal imaging, which also aided in surgical planning.

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma of the Duodenum.

Monomorphic epitheliotropic intestinal T-cell lymphomas (MEITLs) are rare neoplasms that carry a poor prognosis. MEITLs originating in the duodenum are uncommon. There are only 3 published case reports of primary duodenal MEITLs.

Influence of symmetry breaking on the absorption spectrum of crystal violet: from isolated cations at 5 K to room temperature solutions.

We report the resolution of a long-standing puzzle in molecular spectroscopy: the origin of the shoulder in the room temperature solution absorption spectrum of crystal violet (CV) - an archetypal cationic triphenylmethane dye. This was achieved by comparing experimental and theoretical results for CV in solution at room temperature and as an isolated cation in gas-phase at 5 K. The two lowest energy electronically excited states involved in the visible region absorption are degenerate and coupled a Jahn-Teller (JT) mechanism involving phenyl torsions, making CV particularly sensitive to environmental perturbations.

Revisiting the Immunometabolic Basis for the Metabolic Syndrome from an Immunonutritional View.

Metabolic syndrome (MetS) implies different conditions where insulin resistance constitutes a major hallmark of the disease. The disease incurs a high risk for the development of cardiovascular complications, and takes its toll in regard to the gut-liver axis (pancreas, primary liver and colorectal)-associated immunity. The modulation of immunometabolic responses by immunonutritional factors (IFs) has emerged as a key determinant of the gut-liver axis' metabolic and immune health.