High-Throughput Drug Screening in Chondrosarcoma Cells Identifies Effective Antineoplastic Agents Independent of IDH Mutation.

The term chondrosarcoma refers to a rare and heterogeneous group of malignant cartilaginous tumors that are typically resistant to chemotherapy and radiotherapy. Metastatic chondrosarcoma has a poor prognosis, and effective systemic therapies are lacking. Isocitrate dehydrogenase (IDH) mutations represent a potential therapeutic target, but IDH inhibitors alone have shown limited clinical efficacy to date.

Lack of genotoxicity and subchronic toxicity in safety assessment studies of formulation.

A powder formulation of viable bacteria (AMUC) was evaluated in a 90-day repeated-dose toxicity study in rats and a battery of genotoxicity studies to evaluate AMUC as a food ingredient. All studies followed Organisation for Economic Co-operation and Development protocols (OECD TG 408, 471 473, 474). AMUC was administered to rats gavage at 0, 500, 1000, and 2000 mg/kg body weight/day (equivalent to 0, 4.

Exploratory analysis of factors influencing hospital preferences among the Lebanese population: a cross-sectional study.

Objectives: The primary aim of this research is to uncover the underlying factors that shape hospital selection criteria among individuals in Lebanon.

Design: Cross-sectional study.

Setting: A survey was circulated across social media platforms and messaging applications in Lebanon from February to May 2023.

β-glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice.

Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG), a polysaccharide constituent of fungal cellular structures, exhibits potent immunomodulatory activities. The investigational focus was on the anti-asthmatic and anti-ferroptotic properties of beta-glucan nanoparticles (BG-NPs) in a murine model of allergic asthma induced by ovalbumin (OVA).

Investigation of outcomes following transcatheter edge to edge repair of the mitral valve versus medical management alone in patients with cardiogenic shock and mitral regurgitation.

Study Objective: Assessing if Transcatheter Edge to Edge Repair (TEER) with Mitraclip™ in patients with moderate to severe mitral regurgitation (MR) and cardiogenic shock (CS) improves outcomes compared to medical management alone.

Design: A single-center, retrospective study was performed in an urban tertiary referral center.

Setting: Rush University Medical Center, United States.