Extreme Nipple-Sparing Mastectomy: Feasibility of Nipple Preservation and Immediate Reconstruction in Breasts Weighing Over 600 Grams in a Cohort of 43 Patients.

Limited data exist on complication rates in nipple-sparing mastectomy (NSM) in patients with large-volume breasts. Our aim was to evaluate the early complication rates of NSM with immediate reconstruction in a consecutive cohort of patients with large-volume breasts. After IRB approval, patients treated with prophylactic or therapeutic NSM and immediate reconstruction from January 2020 to June 2022 at our health network were identified.

Insights into the start-up of acidic nitritation using conventional activated sludge: Process dynamics, nitrifiers succession, and pilot-scale demonstration.

Acidic nitritation driven by acid-tolerant ammonia-oxidizing bacteria (AOB) has gained wide attention due to its potential in sustainable wastewater and sludge treatment. However, limited knowledge of initiating acidic nitration using conventional activated sludge hindered the wider studies and application of this technology at lab- and field-scale. This study evaluates three strategies for initiating acidic nitritation: a constant low hydraulic retention time (HRT); an extended initial HRT followed by manual HRT reduction; and pH-controlled HRT.

Efficacy and Safety of BI 1358894 in Patients With Borderline Personality Disorder: Results of a Phase 2 Randomized, Placebo-Controlled, Parallel Group Dose-Ranging Trial.

To provide proof-of-concept (PoC), dose-range finding, and safety data for BI 1358894, a TRPC4/5 ion channel inhibitor, in patients with borderline personality disorder (BPD). This was a phase 2, multinational, randomized, double-blind, placebo controlled trial. Patients were randomized to oral placebo or BI 1358894 (5 mg, 25 mg, 75 mg, or 125 mg) once daily in a 2.