Prosodic variation between contexts in infant-directed speech.

Speakers consider their listeners and adjust the way they communicate. One well-studied example is the register of infant-directed speech (IDS), which differs acoustically from speech directed to adults. However, little work has explored how parents adjust speech to infants across different contexts.

Comprehensive meta-analysis reveals distinct gene expression signatures of MASLD progression.

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), pose significant risks of severe fibrosis, cirrhosis, and hepatocellular carcinoma. Despite their widespread prevalence, the molecular mechanisms underlying the development and progression of these common chronic hepatic conditions are not fully understood. Here, we conducted the most extensive meta-analysis of hepatic gene expression datasets from liver biopsy samples to date, integrating 10 RNA-sequencing and microarray datasets (1,058 samples).

Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis.

Background: Recent studies suggest that proteomic cargo of extracellular vesicles (EVs) may play a role in metabolic improvements following lifestyle interventions. However, the relationship between changes in liver fat and circulating EV-derived protein cargo following intervention remains unexplored.

Methods: The study cohort comprised 18 Latino adolescents with obesity and hepatic steatosis (12 males/6 females; average age 13.

The Journal Club: Highlights on Recent Papers-13.

We are delighted to share with you our thirteenth Journal Club and highlight some of the most interesting papers published recently [...