Publications by authors named "J F Demonet"
Objectives: Higher-educated patients with Alzheimer disease (AD) can harbor greater neuropathologic burden than those with less education despite similar symptom severity. In this study, we assessed whether this observation is also present in potential preclinical AD stages, namely in individuals with subjective cognitive decline and clinical features increasing AD likelihood (SCD+).
Methods: Amyloid-PET information ([F]Flutemetamol or [F]Florbetaben) of individuals with SCD+, mild cognitive impairment (MCI), and AD were retrieved from the AMYPAD-DPMS cohort, a multicenter randomized controlled study.
The possibility of flexibly retrieving our memories using a first-person or a third-person perspective (1PP or 3PP) has been extensively investigated in episodic memory research. Here, we used a Virtual Reality-based paradigm to manipulate the visual perspective used during the encoding stage to investigate age-related differences in the formation of memories experienced from 1PP vs. 3PP.
View Article and Find Full Text PDFImportance: Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of appropriately designed studies demonstrating its clinical effect.
Objective: To assess the clinical effect of amyloid PET in memory clinic patients.
Article Synopsis
- - Observational studies suggest that improved vascular health and healthier lifestyles may help prevent dementia and cognitive decline, but the aging population requires more focused prevention strategies to reduce its prevalence and impact.
- - Evidence supports the effectiveness of preventive interventions for individuals at high risk for dementia, even those with normal cognitive function.
- - The text outlines recommendations for establishing second-generation memory clinics (Brain Health Services) aimed at ethical dementia prevention, detailing key interventions like risk assessment, communication, multi-domain risk reduction, and cognitive enhancement strategies.