Publications by authors named "J F Darbyshire"
The protracted form of COVID-19 known as 'long covid' was first described in 2020. Its symptoms, course and prognosis vary widely; some patients have a multi-system, disabling and prolonged illness. In 2021, ring-fenced funding was provided to establish 90 long covid clinics in England; some clinics were also established in Scotland and Wales.
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- Multidisciplinary teams (MDTs) in these clinics built knowledge through shared practices and focused on either patient rehabilitation or understanding the condition's underlying biological damage.
- Conflicts sometimes arose between MDTs when patients shared online narratives about microscopic damage, highlighting differences in treatment approaches and understandings of long covid.
Pathophysiological Mechanisms in Long COVID: A Mixed Method Systematic Review.
Int J Environ Res Public Health
April 2024
Introduction: Long COVID (LC) is a global public health crisis affecting more than 70 million people. There is emerging evidence of different pathophysiological mechanisms driving the wide array of symptoms in LC. Understanding the relationships between mechanisms and symptoms helps in guiding clinical management and identifying potential treatment targets.
View Article and Find Full Text PDFBackground: Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality standards to reduce a so-called "postcode lottery" of care. The original aim of this study-to examine the nature of quality in long covid care and reduce unwarranted variation in services-evolved to focus on examining the reasons why standardizing care was so challenging in this condition.
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- The study focuses on improving patient monitoring after discharge from Intensive Care Units (ICUs) by developing an enhanced scoring system that predicts adverse events using ongoing vital signs and an initial risk score from ICU discharge.
- A modified Delphi process helped identify relevant variables from electronic records, and a logistic regression model estimated the risk of complications, combining static and dynamic scoring to provide continuous updates on patient risk.
- Validation of the scoring system demonstrated its effectiveness in predicting ICU readmissions or in-hospital deaths within 24 hours, outperforming existing scoring systems like the National Early Warning Score (EWS).