Publications by authors named "J F Darby"

Achieving high battery performance from low-cost, easily synthesisable electrode materials is crucial for advancing energy storage technologies. Metal organic frameworks (MOFs) combining inexpensive transition metals and organic ligands are promising candidates for high-capacity cathodes. Iron-chloranilate-water frameworks are herein reported to be produced in aqueous media under mild conditions.

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The adult mammalian heart is unable to undergo cardiac repair, limiting potential treatment options after cardiac damage. However, the fetal heart is capable of cardiac repair. In preparation for birth, cardiomyocytes (CMs) undergo major maturational changes that include exit from the cell cycle, hypertrophic growth, and mitochondrial maturation.

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Article Synopsis
  • High-grade serous ovarian cancer (HGSC) shows resistance to immunotherapy but some patients have partial or complete responses, indicating a potential molecular basis for immunity in specific subpopulations.
  • An algorithm called CONSTRU was developed to analyze gene expression profiles in HGSC and identify genetic factors that influence the effectiveness of anti-tumor immunity, resulting in a stratification signature (STRATsig) that divides patients into groups based on their immune response.
  • Results indicated that patient survival and immune function varied significantly among these groups, with one group (S-T1) exhibiting strong immune suppression and dysfunction, while another group (S-T3) showed improved immune function, antigen presentation, and survival benefits correlated with genetic mutations.
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Programming effects of maternal undernutrition on fetal metabolic and cardiovascular systems are well elucidated, yet a detailed characterization of maternal haemodynamics is not available. This study used comprehensive cardiovascular magnetic resonance (CMR) imaging to quantify maternal haemodynamics after 29 days (111-140 days) of late-gestation undernutrition (LGUN) in pregnant sheep. Control ewes received 100% of metabolizable energy requirements (MERs, n = 15), whereas LGUN ewes were globally nutrient restricted to 50% MER (n = 18), with a subset of fetuses undergoing continuous glucose infusion (LGUN + G, n = 6/18).

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Knowledge of how animals respond to weather and changes in their physical environment is increasingly important, given the higher frequency of extreme weather recorded in recent years and its forecasted increase globally. Even species considered to be highly adapted to extremes of weather, as albatrosses are to strong winds, may be disadvantaged by shifts in those extremes. Tracked albatrosses were shown recently to avoid storms and the strongest associated winds.

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