Publications by authors named "J F Crofts"

Article Synopsis
  • The study explores synchronization and coherence in a network of delayed Wilson-Cowan nodes, focusing on how intra-nodal and inter-nodal delays impact communication within and between brain regions.
  • By analyzing various network structures, including the macaque monkey's cortical layout, the research examines how factors like network configuration, coupling strength, and time delays influence global dynamics, specifically synchrony and metastability.
  • The findings reveal significant regions of synchronized states with instabilities, particularly identifying unique time-dependent behaviors in the cortical network that are vital for complex information processing, as opposed to simpler behaviors in toy models.
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Macrophages are a type of white blood cell that play a significant role in determining the inflammatory response associated with a wide range of medical conditions. They are highly plastic, having the capacity to adopt numerous polarisation states or 'phenotypes' with disparate pro- or anti-inflammatory roles. Many previous studies divide macrophages into two categorisations: M1 macrophages are largely pro-inflammatory in nature, while M2 macrophages are largely restorative.

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Caesarean scar pregnancy (CSP) occurs when the gestational sac implants in the region of a scar from a previous caesarean delivery. CSP can lead to life-threatening complications, including severe haemorrhage, uterine rupture, placenta accreta spectrum (PAS) and hysterectomy. A 40-year-old woman with one previous caesarean was referred to the specialist centre at 17 weeks of gestation with concerns about CSP.

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Macrophages play a wide range of roles in resolving the inflammatory damage that underlies many medical conditions and have the ability to adopt different phenotypes in response to different environmental stimuli. Categorising macrophage phenotypes exactly is a difficult task, and there is disparity in the literature around the optimal nomenclature to describe these phenotypes; however, what is clear is that macrophages can exhibit both pro- and anti-inflammatory behaviours dependent upon their phenotype, rendering mathematical models of the inflammatory response potentially sensitive to their description of the macrophage populations that they incorporate. Many previous models of inflammation include a single macrophage population with both pro- and anti-inflammatory functions.

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