Publications by authors named "J F Cote"
Background: Patients who experienced acute kidney injury (AKI) may benefit from dedicated care following hospital discharge. Most of these patients will be followed by primary care providers. There is a lack of data on current practices and comfort for these care providers when offering post-AKI care.
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- The study investigated the occurrence and risk factors of adverse events (AEs) related to intravenous immunoglobulin (IVIG) therapy in hospitalized children under 18 years old.
- A total of 228 patients were reviewed, resulting in 478 IVIG treatments, with mild reactions like fever and headache being the most common, although some reactions were severe.
- Key predictors of IVIG-AEs included older age, dehydration, allergies, being on the first treatment, and receiving higher doses, while concurrent steroid use seemed to reduce risk.
Article Synopsis
- - The debate around first line autologous stem cell transplantation (ASCT) for multiple myeloma (MM) has intensified, especially for standard-risk patients, while high-risk patients still face poor treatment outcomes.
- - Current best practices for transplant-eligible MM (TEMM) now include a quadruplet induction therapy that combines an anti-CD38 monoclonal antibody with a proteasome inhibitor and an immunomodulatory drug, followed by maintenance therapy.
- - The Canadian Consensus Guideline Consortium (CGC) is providing recommendations on various aspects of treatment for TEMM, including ASCT eligibility, induction therapy, and management of high-risk patients, with plans to review and update these guidelines regularly.
Background: Smoking in pregnancy continues to cause significant morbidity to mothers and babies and contributes to tremendous costs to society. Maternal-fetal attachment (MFA) may differentiate smokers who quit or pregnant smokers from non-smokers. Researchers have recommended utilizing interventions that improve MFA to help decrease smoking within pregnancy.
View Article and Find Full Text PDFA toxicokinetic model of the pyrethroid insecticide lambda-cyhalothrin (LCT) was developed to relate absorbed doses to urinary cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylic acid (CFMP) metabolite levels used as a biomarker of exposure. The model then served to reconstruct absorbed doses in agricultural workers and their probability of exceeding the EFSA Acceptable occupational Exposure Level (AOEL). The toxicokinetic model was able to reproduce the temporal profiles of CFMP in the urine of operators spraying pesticides using the optimized model parameters (adjusted to human volunteer data).
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