Publications by authors named "J F Clements"
Objective: The objective of this study was to assess antihypertensive and lipid-lowering treatment changes in participants receiving semaglutide 2.4 mg versus placebo across pooled populations from five Semaglutide Treatment Effect in People with Obesity (STEP) trials.
Methods: Efficacy and safety of semaglutide 2.
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.
View Article and Find Full Text PDFBackground: Prostate cancer (PCa) is a commonly diagnosed cancer. Genome-wide association studies have implicated Iroquois homeobox 4 (IRX4) in PCa susceptibility, yet its functional roles remain unclear. We discovered a 78-amino acid micropeptide (miPEP, IRX4_PEP1), encoded from the alternative start site within the IRX4 gene.
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- Viral encephalitis poses a significant public health concern, especially with limited diagnostic and treatment methods available.
- SIV-infected macaques serve as a model for studying HIV, with about 60% of untreated pigtail macaques rapidly developing SIV encephalitis (SIVE).
- Research shows that immune responses in SIVE macaques lead to specific brain lesions and inflammatory markers, and the presence of SIV-specific IgG antibodies can predict SIVE development as early as 21 days post-infection.
Background: Monocytes are susceptible to HIV infection, form HIV reservoirs, and contribute to central nervous system complications (e.g., cognitive impairment) in virally suppressed women with HIV(vsWWH).
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