Publications by authors named "J F Charbonnier"
In this cohort study involving 9399 current and former smokers from the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease study, we assessed the relationship between artificial intelligence-quantified mucus plugs on chest CTs and all-cause mortality. Our results revealed a significant positive association, particularly for those with COPD GOLD stages 1-4, with HRs of 1.18 for 1-2 mucus-obstructed bronchial segments and 1.
View Article and Find Full Text PDFBackground: The assessment of bronchus-artery (BA) metrics on chest CT is important for detecting airway abnormalities. It is less clear how BA metrics are dependent on lung volume.
Methods: CTs were obtained from a COPDGene substudy investigating the impact of radiation dose on lung density.
This study investigated the impact of bronchoscopic lung volume reduction treatment using endobronchial valves (EBV) on diaphragm configuration. We successfully analyzed the diaphragm index using a newly developed quantitative computed tomography (QCT) tool before and after EBV treatment in forty patients with severe emphysema. We evaluated whether changes in the diaphragm index were associated with improvements in forced expiratory volume in 1 s (FEV), residual volume (RV), Saint Georges Respiratory Questionnaire (SGRQ), and 6-min walking distance (6MWD) using Spearman's rho.
View Article and Find Full Text PDFArticle Synopsis
- DNA-dependent protein kinase (DNA-PK) plays a crucial role in repairing DNA double-strand breaks and is a target for cancer therapies to enhance the effectiveness of radiation treatments.
- Researchers have developed new oxindole Ku-DNA binding inhibitors (Ku-DBis) that show better cellular uptake and strong inhibition of Ku proteins, demonstrating variable effectiveness across different non-small cell lung cancer (NSCLC) cell lines.
- In vivo studies reveal that Ku-DBis can block DNA-PK autophosphorylation, alter DNA damage responses, and lower tumor cell growth, indicating their potential use in improving cancer treatment outcomes.
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) has been linked to small vessel abnormalities, contributing to increased mortality, but their specific impact is still unclear.
- In a study involving 7,903 individuals, researchers analyzed small artery and vein dimensions and found that high volumes of both were independently associated with increased mortality rates.
- The findings suggest that abnormal small vessel sizes in smokers are significant for mortality risk, highlighting the need for further research into the causes and effects of these vascular changes.