Publications by authors named "J F Butzer"
Article Synopsis
- TRIM21 is a key player in the immune system, guiding antibody responses and affecting immune signaling.
- The study investigates how TRIM21 interacts with engineered antibodies to neutralize viruses, utilizing advanced analytical techniques.
- Findings suggest a unique dual binding mechanism that enhances TRIM21's ability to target viruses for degradation, offering insights for new antiviral therapies and strategies.
Objectives: To compare the effectiveness of two different interventions that promote physical activity in individuals with traumatic spinal cord injury (SCI) and determine the effect of relapse prevention.
Methods: A sequential, multiple assignment, randomized trial was conducted at a universally designed community-based exercise facility. Participants were individuals with traumatic SCI, >3 months post injury, levels C5 to T12, age ≥18 years ( = 79).
Objective: Exploratory application of the Rasch Measurement (RM) Model for evidence for reproducibility, conceptual/content validity, and structural validity of the Moorong Self-Efficacy Scale (MSES).
Study Design: Secondary RM analysis of data collected in a randomized controlled trial comparing two exercise interventions for persons living with spinal cord injury (SCI).
Setting: Community-dwelling persons living with SCI enrolled in an exercise study.
The presence of di-/multi-meric forms of soluble target in biological samples can interfere in anti-drug antibody (ADA) assays, leading to increased background values and potentially false positivity. The authors investigated the use of the high ionic strength dissociation assay (HISDA) to reduce target interference in two different ADA assays. Interference caused by homodimeric FAP was successfully eliminated to enable cut point determination after applying HISDA.
View Article and Find Full Text PDFObjective: To demonstrate feasibility of generating predictive short-term individual trajectory recovery models after acute stroke by extracting clinical data from an electronic medical record (EMR) system.
Design: Single-group retrospective patient cohort design.
Setting: Stroke rehabilitation unit at an independent inpatient rehabilitation facility (IRF).