Publications by authors named "J F Brick"
Importance: Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking.
Objective: To conduct a systematic review and meta-analysis to assess the prevalence of BPD in very low birth weight (≤ 1,500 g) or very low gestational age (< 32 weeks) neonates.
The venom-containing barb attached to their 'whip-like' tail provides stingrays a defensive mechanism for evading predators such as sharks. From human encounters, dermal stingray envenomation is characterized by intense pain often followed by tissue necrosis occurring over several days to weeks. The bioactive components in stingray venoms (SRVs) and their molecular targets and mechanisms that mediate these complex responses are not well understood.
View Article and Find Full Text PDFBackground: Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.
Methods: We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021-August 2021 in Jefferson County, Kentucky (USA). Our susceptible ( ), vaccinated ( ), variant-specific infected ( and ), recovered ( ), and seropositive ( ) model ( ) tracked prevalence longitudinally.
To evaluate community-wide prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using stratified simple random sampling. We obtained data for the prevalence of SARS-CoV-2 in Jefferson County, Kentucky, from adult random (n = 7296) and volunteer (n = 7919) sampling over 8 waves from June 2020 through August 2021. We compared results with administratively reported rates of COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- Large-scale SARS-CoV-2 vaccination's impact on virus levels in wastewater and hospitalization rates remains unclear, even after extensive assessments.
- A study conducted in Jefferson County, Kentucky, from April to August 2021 linked weekly wastewater data with vaccination and hospitalization statistics, revealing that a 64% vaccination rate led to a 61% decrease in virus incidence.
- The emergence of the Delta variant dramatically increased infection rates, leading to a significant rise in wastewater virus concentration, with hospitalization closely correlating with wastewater levels, highlighting the need for ongoing environmental monitoring in public health.