Publications by authors named "J F Bresnahan"
Traumatic brain injury (TBI) has long been a leading cause of death and disability, yet research has failed to successfully translate findings from the pre-clinical, animal setting into the clinic. One factor that contributes significantly to this struggle is the heterogeneity observed in the clinical setting where patients present with injuries of varying types, severities, and comorbidities. Modeling this highly varied population in the laboratory remains challenging.
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- - The complex nature of spinal cord injury (SCI) creates challenges for translating research into practical treatments, leading to a need for advanced data science solutions to manage diverse injury data and outcomes.
- - To address privacy concerns with sensitive data, a Private Data Commons for SCI (PDC-SCI) has been developed, enabling secure, organized data sharing among researchers for collaborative studies.
- - An example of PDC-SCI in action is demonstrated through the VA Gordon Mansfield SCI Consortium, which integrates various data types to enhance research insights and knowledge discovery in SCI.
Article Synopsis
- - The study aimed to compare the motor examinations done by the clinical neurosurgery team with the ISNCSCI assessments, since the latter can be time-consuming and impractical during acute spinal cord injuries.
- - Researchers analyzed data from the TRACK-SCI registry, which included 72 pairs of motor examinations from 63 patients, and found strong correlations between the two methods, indicating that neurosurgery motor examinations can effectively substitute for ISNCSCI exams.
- - The results showed a very high agreement between the scores from both types of examinations with low bias, suggesting that clinical neurosurgery evaluations are reliable for assessing neurological function after spinal cord injuries.
Background: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post-injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non-neuronal markers or pan-neuronal markers with constitutive expressions.
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