Systemic and arterial hemodynamic effects of nifedipine (20 mg) in mild-to-moderate hypertension.

Systemic and arterial hemodynamic effects of the new 20 mg tablet of nifedipine were studied in seven patients with mild-to-moderate essential hypertension. Hemodynamics of the forearm arterial circulation were investigated using a new pulsed Doppler system, enabling the simultaneous determination of the brachial artery diameter and the arterial blood flow velocity. After nifedipine administration, blood pressure decreased significantly, due to a fall in total peripheral resistance.

Antihypertensive effects and plasma levels of guanfacine in man.

The antihypertensive effect and the plasma levels of guanfacine were studied for two months in 25 patients with sustained essential hypertension. In three patients, blood pressure was unchanged. In ten patients, blood pressure returned to the normal range within 15 days, at a daily dose of 2 mg.