Publications by authors named "J F Bernaudin"
Article Synopsis
- - Platelet aggregation in the lungs may contribute to thrombocytopenia during acute pulmonary hypertension (PH) decompensation, as observed in lung transplant patients.
- - A study involving 16 patients identified a significantly higher number of platelet aggregates in those experiencing thrombocytopenia compared to control patients without PH.
- - Scanning electron microscopy revealed that the capillaries in the lungs of patients with acute PH decompensation were filled with these platelet aggregates, indicating a potential mechanism for the condition.
In this review, the infectious complications observed in sarcoidosis are considered from a practical point of view to help the clinician not to overlook them in a difficult context, as pulmonary sarcoidosis makes the recognition of superinfections more difficult. An increased incidence of community-acquired pneumonia and of opportunistic pneumonia has been reported, especially in immunosuppressed patients. Pulmonary destructive lesions of advanced sarcoidosis increase the incidence of chronic pulmonary aspergillosis and infection by other agents.
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- - Fibrotic pulmonary sarcoidosis (fPS) impacts about 20% of patients and is associated with significant health risks and variable prognosis based on factors like fibrosis extent and functional impairment severity.
- - The condition is also affected by complications such as acute exacerbations and infections, but its natural progression, particularly the risk of ongoing fibrosis, remains unclear.
- - Managing fPS is complex and may involve anti-inflammatory treatments, rehabilitation, and, in certain cases, antifibrotic therapy or lung transplantation.