Publications by authors named "J F Abril"
Article Synopsis
- CAPTVRED is a user-friendly tool designed for analyzing viral metagenomics data obtained from Target Enrichment Sequencing, especially in complex samples like environmental matrices.
- It aims to provide comprehensive and reproducible results while reducing analysis time and computational costs.
- The source code and test datasets are freely accessible on GitHub, making it easier for researchers to implement and customize the tool.
Article Synopsis
- Recognition of the intron branchpoint in spliceosome assembly is crucial for mRNA structure and quantity, involving a branchpoint sequence motif that varies across eukaryotic genomes.
- SF1 and QKI proteins compete for recognition of a specific intron branchpoint sequence (ACUAA), where SF1 promotes exon inclusion while QKI represses it, affecting splicing outcomes.
- The findings suggest that QKI acts as a splicing repressor by blocking SF1 binding at dual branchpoints, indicating a co-evolution of branchpoint sequences for precise regulation of gene expression in diverse organisms.
Article Synopsis
- - Calcium signaling is crucial for how neurons communicate and for muscle movement, with junctophilin proteins being key components of calcium channels in cells.
- - The study investigated the effects of downregulating a specific junctophilin gene through RNA interference (RNAi) by feeding bacteria that target this gene.
- - Results showed that reducing the gene's expression changed the physical structure of cells and decreased movement in wild-type organisms, supporting the idea that this gene is important for muscle function.
The evolution of insects has been marked by the appearance of key body plan innovations that promoted the outstanding ability of this lineage to adapt to new habitats, boosting the most successful radiation in animals. To understand the evolution of these new structures, it is essential to investigate which genes and gene regulatory networks participate during the embryonic development of insects. Great efforts have been made to fully understand gene expression and gene regulation during the development of holometabolous insects, in particular Drosophila melanogaster.
View Article and Find Full Text PDFThe COVID-19 pandemic has underscored the importance of understanding the role of animals in the transmission of coronaviruses (CoVs) and their impact on human health. A One Health approach, integrating human, animal, and environmental health, is essential for effective CoVs control. Next-generation sequencing has played a pivotal role in identifying and monitoring the evolution of novel CoVs strains, like SARS-CoV-2.
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