Publications by authors named "J F A Madeira"
Article Synopsis
- Peritoneal tuberculosis is a rare form of TB that occurs outside the lungs, primarily affecting individuals in countries with high TB prevalence, making travel from these areas a risk factor.
- Diagnosing this condition is challenging due to overlapping symptoms with other illnesses, which can delay treatment and worsen outcomes.
- A case study highlights a woman in her mid-50s who experienced severe symptoms, leading to various diagnostic procedures, with TB ultimately isolated from her fluid, allowing her to successfully complete a 6-month anti-TB treatment.
Direct MultiSearch optimization of TPMS scaffolds for bone tissue engineering.
Comput Methods Programs Biomed
December 2024
Background: Scaffolds designed for tissue engineering must consider multiple parameters, namely the permeability of the design and the wall shear stress experienced by the cells on the scaffold surface. However, these parameters are not independent from each other, with changes that improve wall shear stress, negatively impacting permeability and vice versa. This study introduces a novel multi-objective optimization framework using Direct MultiSearch (DMS) to design triply periodic minimal surface (TPMS) scaffolds for bone tissue engineering.
View Article and Find Full Text PDFTerminal ileitis is a common finding in clinical practice and is often associated with Crohn's disease. However, other pathologies must be considered particularly those resulting from side effects of drugs. We report a case of an 18-year-old female that underwent renal transplant under mycophenolate sodium, tacrolimus, and prednisolone admitted for abdominal pain, diarrhea and weight loss.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the prevalence of irritable bowel syndrome (IBS)-like symptoms and anxiety in patients with ulcerative colitis (UC) who are in clinical remission.
- Among 106 UC patients, 29 met the criteria for IBS, and those with IBS showed higher levels of subclinical inflammation and anxiety compared to those without IBS.
- The findings suggest that effective treatment for UC should not only focus on inflammation but also address the psychological aspects, as IBS-like symptoms are linked to anxiety and inflammation.
Article Synopsis
- - Whipple's disease is a rare chronic infection that affects multiple systems and is often marked by symptoms like weight loss, diarrhea, and joint pain, but can also present as localized disease, acute infection, or be asymptomatic.
- - Diagnosis involves examining duodenal biopsies and using PCR to analyze specific genetic material from the causative agent.
- - A case study highlights a middle-aged man with ongoing joint pain and gastrointestinal issues, illustrating how the rarity of Whipple's disease makes it challenging to diagnose despite its diverse symptoms.