Publications by authors named "J Eugene Huffstutter"
Article Synopsis
- The study investigates the safety and effectiveness of the live attenuated zoster vaccine (ZVL) in adults aged 50 and older who are on tumor necrosis factor inhibitors (TNFis) for various inflammatory diseases.
- Conducted as a randomized, placebo-controlled trial with 617 participants, it assesses immune responses to the vaccine and monitors for any cases of varicella infection or shingles.
- Results show no confirmed varicella infections among participants by week 6, indicating a cumulative incidence of 0.0%, suggesting that the ZVL is safe for patients receiving TNFis in this study.
Background: The efficacy and safety of ixekizumab (IXE) with and without continuous concomitant methotrexate (MTX), for up to 52 weeks of treatment, were evaluated in patients with active psoriatic arthritis (PsA).
Methods: Patients with active PsA who were biologic-naive (SPIRIT-P1) or had prior inadequate response to tumor necrosis factor inhibitors (SPIRIT-P2) were randomized to 80 mg IXE every 4 (IXE Q4W) or 2 weeks (IXE Q2W), after a 160-mg initial dose. In this post hoc analysis, efficacy and safety were assessed up to week 52 in the subgroups of patients who received (i) IXE as monotherapy and (ii) IXE along with a stable dose of MTX (no dose tapering or increase).
Article Synopsis
- The study looked at how well a medicine called golimumab worked for people with rheumatoid arthritis who weren't improving on other treatments like etanercept or adalimumab.
- It involved 433 patients who received golimumab along with methotrexate for treatment and were monitored over several weeks.
- The results showed that some patients improved, but those who switched to different types of golimumab had mixed results, and the study had some issues with patients leaving the trial early.
Medical audits have become commonplace in the United States. A variety of companies service government and private payers to document accuracy of medical services provided as reflected in the medical record. When audited, the physician may not understand the nature of the inquiry, jurisdictions, methods, or purpose.
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