Publications by authors named "J Escriva Peiro"
Background: External ventricular drain (EVD) insertion is one of the most commonly performed neurosurgical procedures. Herein, we introduce a new concept of a cranial fixation device for insertion of EVDs, that reduces reliance on freehand placement and drilling techniques and provides a simple, minimally invasive approach that provides strong fixation to minimal thickness skulls.
Methods: An experimental device for catheter insertion and fixation was designed and tested in both ex-vivo and in-vivo conditions to assess accurate cannulation of the ventricle and to test the strength of fixation to the skull.
Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. While the ensuing compression to the fetal lung causes lung hypoplasia, specific cellular phenotypes and developmental signaling defects in the alveolar epithelium in CDH are not fully understood. Employing lung samples from human CDH, a surgical lamb model and a nitrogen rat model, we investigate whether lung compression impairs alveolar epithelial differentiation and Yes-associated protein (YAP)-mediated mechanosensing.
View Article and Find Full Text PDFProof of concept testing of a vascular closure device for use in fetal surgery.
J Matern Fetal Neonatal Med
December 2025
Objective: Prior clinical findings have demonstrated that maternal laparotomy with trans-amniotic trans-uterine suturing of the fetoscopic port site during in utero myelomeningocele repair reduces the risk of membrane rupture. However, due to laparotomy-associated morbidity, we aimed to explore the feasibility of using a vascular closure device for percutaneous trans-amniotic trans-uterine suturing.
Methods: This IRB and IACUC-exempt study utilized 2 strategies for proof-of-concept testing of using the Abbott Perclose ProStyle Device for suture placement; 1.
Article Synopsis
- * Bone morphogenetic proteins (BMPs) influence cell development in the central nervous system and were found to increase astrogenesis in MMC conditions.
- * The study showed that the PLA/PCL patch is biocompatible and can deliver Noggin, a BMP antagonist, which helps reduce the negative effects of BMP2 and BMP4 on neural precursor cells.
Article Synopsis
- The study aimed to describe a new prenatal technique for myelomeningocele (MMC) repair using a minimally invasive method with a decellularized human umbilical cord graft for covering the spinal defect.
- A cohort of 57 patients from an ongoing study showed positive postnatal outcomes, with most patients achieving independent or therapeutic ambulation and a low incidence of serious complications like CSF leaks.
- Findings include a significant rate of complete reversal of hindbrain herniation at birth and a manageable percentage of spinal inclusion cysts that required minimal surgical intervention.