Publications by authors named "J Engesser"
Th17 cells play crucial roles in host defense and the pathogenesis of autoimmune diseases in the skin. While their differentiation mechanisms have been extensively studied, the origin of skin Th17 cells remains unclear. In this study, we analyzed single-cell RNA-sequencing data and identify the presence of Th17 cells in the human thymus.
View Article and Find Full Text PDFOptimized protocol for the multiomics processing of cryopreserved human kidney tissue.
Am J Physiol Renal Physiol
November 2024
Article Synopsis
- The study talks about collecting kidney tissue samples from patients to use them for research and understanding diseases better.
- They found a way to keep these tissues preserved without needing super-cold liquid nitrogen, which makes it easier for doctors to use them in their work.
- By testing these samples with advanced technology, they hope to identify new ways to help prevent and treat kidney diseases in the future.
Article Synopsis
- ANCA-associated vasculitis is a severe autoimmune disease that can lead to kidney failure due to crescentic glomerulonephritis, and current treatments using non-specific immunosuppressive drugs may be insufficient and carry risks.
- Researchers analyzed kidney samples from 34 patients with ANCA-GN and identified specific inflammatory T cells that contribute to the disease, leading to the discovery of ustekinumab as a promising targeted treatment.
- In a trial, four patients with recurring ANCA-GN treated with ustekinumab and low-dose cyclophosphamide showed significant improvement in kidney function and overall health, indicating potential for this approach to be further explored in clinical settings.